Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited
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چکیده
منابع مشابه
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis.
Cancer cells display high rates of aerobic glycolysis, a phenomenon known historically as the Warburg effect. Lactate and pyruvate, the end products of glycolysis, are highly produced by cancer cells even in the presence of oxygen. Hypoxia-induced gene expression in cancer cells has been linked to malignant transformation. Here we provide evidence that lactate and pyruvate regulate hypoxia-indu...
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2010
ISSN: 1752-0509
DOI: 10.1186/1752-0509-4-58